Transition to organic dairy farming implies management changes, including restrictions in the use of antibiotics for mastitis control, which could affect udder health. As a result, more research is needed to better understand mastitis epidemiology on organic dairies. The objectives of this study were to investigate the relationship between presence and persistence of IMI in the first 35 DIM and SCC and milk production during the first 6 months of lactation on first-lactation organic dairy cows. This study provides important information that could be used to improve the utility of IMI screening in early lactation heifers on organic dairy farms.